Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease
Identifieur interne : 000820 ( Main/Exploration ); précédent : 000819; suivant : 000821Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease
Auteurs : Joseph J. Locascio [États-Unis] ; Shirley Eberly [États-Unis] ; Zhixiang Liao [États-Unis] ; Ganqiang Liu [États-Unis] ; Ashley N. Hoesing [États-Unis] ; Karen Duong [États-Unis] ; Ana Trisini-Lipsanopoulos [États-Unis] ; Kaltra Dhima [États-Unis] ; Albert Y. Hung [États-Unis] ; Alice W. Flaherty [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Michael T. Hayes [États-Unis] ; Anne-Marie Wills [États-Unis] ; U. Shivraj Sohur [États-Unis] ; Nicte I. Mejia [États-Unis] ; Dennis J. Selkoe [États-Unis] ; David Oakes [États-Unis] ; Ira Shoulson [États-Unis] ; Xianjun Dong [États-Unis] ; Ken Marek [États-Unis] ; Bin Zheng [États-Unis] ; Adrian Ivinson [États-Unis] ; Bradley T. Hyman [États-Unis] ; John H. Growdon [États-Unis] ; Lewis R. Sudarsky [États-Unis] ; Michael G. Schlossmacher [États-Unis] ; Bernard Ravina [Canada] ; Clemens R. Scherzer [États-Unis]Source :
- Brain [ 0006-8950 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (etiology), Cognition Disorders (genetics), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Gene Expression Regulation, Genetic Testing, Humans, Male, Microarray Analysis, Middle Aged, Neuroimaging, Parkinson Disease (complications), Parkinson Disease (diagnostic imaging), Parkinson Disease (genetics), Parkinson Disease (pathology), RNA, Messenger (metabolism), Radionuclide Imaging, Severity of Illness Index, Tropanes, alpha-Synuclein (blood), alpha-Synuclein (genetics).
- MESH :
- chemical , blood : alpha-Synuclein.
- chemical , genetics : alpha-Synuclein.
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins, RNA, Messenger.
- complications : Parkinson Disease.
- diagnostic imaging : Parkinson Disease.
- etiology : Cognition Disorders.
- genetics : Cognition Disorders, Parkinson Disease.
- pathology : Parkinson Disease.
- Aged, Female, Gene Expression Regulation, Genetic Testing, Humans, Male, Microarray Analysis, Middle Aged, Neuroimaging, Radionuclide Imaging, Severity of Illness Index, Tropanes.
Abstract
The α-synuclein gene,
Url:
DOI: 10.1093/brain/awv202
PubMed: 26220939
PubMed Central: 4643625
Affiliations:
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Le document en format XML
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02115</wicri:noRegion></affiliation></author><author><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 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Hung</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. 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University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><wicri:noRegion>NY 14642</wicri:noRegion></affiliation></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea><wicri:noRegion>DC 20007</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea><wicri:noRegion>DC 20007</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF9">9 Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>9 Institute for Neurodegenerative Disorders, New Haven, CT 06510</wicri:regionArea><wicri:noRegion>CT 06510</wicri:noRegion></affiliation></author><author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF10">10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5</wicri:regionArea><wicri:noRegion>Ontario K1H8M5</wicri:noRegion></affiliation></author><author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26220939</idno><idno type="pmc">4643625</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643625</idno><idno type="RBID">PMC:4643625</idno><idno type="doi">10.1093/brain/awv202</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000030</idno><idno type="wicri:Area/Pmc/Curation">000030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000030</idno><idno type="wicri:Area/Pmc/Checkpoint">000354</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000354</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000420</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000420</idno><idno type="wicri:Area/PubMed/Curation">000420</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000420</idno><idno type="wicri:Area/PubMed/Checkpoint">000420</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000420</idno><idno type="wicri:Area/Ncbi/Merge">001C58</idno><idno type="wicri:Area/Ncbi/Curation">001C58</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C58</idno><idno type="wicri:doubleKey">0006-8950:2015:Locascio J:association:between:synuclein</idno><idno type="wicri:Area/Main/Merge">000821</idno><idno type="wicri:Area/Main/Curation">000820</idno><idno type="wicri:Area/Main/Exploration">000820</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease</title><author><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF3">3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><wicri:noRegion>NY 14642</wicri:noRegion></affiliation></author><author><name sortKey="Liao, Zhixiang" sort="Liao, Zhixiang" uniqKey="Liao Z" first="Zhixiang" last="Liao">Zhixiang Liao</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ganqiang" sort="Liu, Ganqiang" uniqKey="Liu G" first="Ganqiang" last="Liu">Ganqiang Liu</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. 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Shivraj Sohur</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Mejia, Nicte I" sort="Mejia, Nicte I" uniqKey="Mejia N" first="Nicte I." last="Mejia">Nicte I. Mejia</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF3">3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><wicri:noRegion>NY 14642</wicri:noRegion></affiliation></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea><wicri:noRegion>DC 20007</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea><wicri:noRegion>DC 20007</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF9">9 Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>9 Institute for Neurodegenerative Disorders, New Haven, CT 06510</wicri:regionArea><wicri:noRegion>CT 06510</wicri:noRegion></affiliation></author><author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF10">10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5</wicri:regionArea><wicri:noRegion>Ontario K1H8M5</wicri:noRegion></affiliation></author><author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author></analytic><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (genetics)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Female</term><term>Gene Expression Regulation</term><term>Genetic Testing</term><term>Humans</term><term>Male</term><term>Microarray Analysis</term><term>Middle Aged</term><term>Neuroimaging</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>RNA, Messenger (metabolism)</term><term>Radionuclide Imaging</term><term>Severity of Illness Index</term><term>Tropanes</term><term>alpha-Synuclein (blood)</term><term>alpha-Synuclein (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Gene Expression Regulation</term><term>Genetic Testing</term><term>Humans</term><term>Male</term><term>Microarray Analysis</term><term>Middle Aged</term><term>Neuroimaging</term><term>Radionuclide Imaging</term><term>Severity of Illness Index</term><term>Tropanes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The α-synuclein gene, <italic>SNCA</italic>, is selectively expressed in blood cells and neurons. Locascio <italic>et al.</italic> reveal a paradoxical reduction in <italic>SNCA</italic> transcript counts in the blood of individuals with early-stage, neuroimaging-supported Parkinson’s disease in three regional, national, and international populations. Low <italic>SCNA</italic> transcript abundance predicted subsequent cognitive decline.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name></noRegion><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T." last="Hayes">Michael T. Hayes</name><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name><name sortKey="Liao, Zhixiang" sort="Liao, Zhixiang" uniqKey="Liao Z" first="Zhixiang" last="Liao">Zhixiang Liao</name><name sortKey="Liao, Zhixiang" sort="Liao, Zhixiang" uniqKey="Liao Z" first="Zhixiang" last="Liao">Zhixiang Liao</name><name sortKey="Liu, Ganqiang" sort="Liu, Ganqiang" uniqKey="Liu G" first="Ganqiang" last="Liu">Ganqiang Liu</name><name sortKey="Liu, Ganqiang" sort="Liu, Ganqiang" uniqKey="Liu G" first="Ganqiang" last="Liu">Ganqiang Liu</name><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name><name sortKey="Mejia, Nicte I" sort="Mejia, Nicte I" uniqKey="Mejia N" first="Nicte I." last="Mejia">Nicte I. Mejia</name><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name><name sortKey="Shivraj Sohur, U" sort="Shivraj Sohur, U" uniqKey="Shivraj Sohur U" first="U." last="Shivraj Sohur">U. Shivraj Sohur</name><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name></country><country name="Canada"><noRegion><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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